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1996-02-27
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Document 0495
DOCN M9630495
TI Langerhans cells and HIV infection.
DT 9603
AU Zambruno G; Giannetti A; Bertazzoni U; Girolomoni G; Istituto
Dermopatico dell' Immacolata, IRCCS, Roma, Italy.
SO Immunol Today. 1995 Nov;16(11):520-4. Unique Identifier : AIDSLINE
MED/96084510
AB Epidermal Langerhans cells (LCs) isolated from individuals infected with
human immunodeficiency virus (HIV-1) harbour HIV-1 proviral DNA and RNA,
indicating productive infection by the virus in vivo. Furthermore,
normal LCs can be infected in vitro by HIV and can present HIV antigens
to helper T cells. Here, Giovanna Zambruno and colleagues discuss the
possibility that LCs of genital mucosae are among the first targets of
HIV infection following sexual contact, and can be involved both in the
transmission of the infection to T cells and in T-cell priming to HIV
antigens. In addition, epidermal LCs might acquire HIV infection from
dermal T cells during transit from blood vessels through the dermis and
may, in turn, represent a reservoir of the virus for continued T-cell
infection.
DE Animal Human HIV Infections/*PATHOLOGY *HIV-1 Langerhans
Cells/*VIROLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE REVIEW
REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).